Even though the shortage of Blk mRNA and you can necessary protein expression from inside the mouse thymocytes doesn’t help these types of data (Fig
Even though the shortage of Blk mRNA and you can necessary protein expression from inside the mouse thymocytes doesn’t help these types of data (Fig The new personal phrase off Blk in B muscle could have been confronted of the report about Blk expression in people thymocytes (10). ? (Fig.1C), step one C), a possible aftereffect of Blk insufficiency towards T-telephone innovation is actually investigated. The new thymuses away from Blk-lacking and handle mice was indeed out-of equal proportions, together with ratios off CD4 and you can CD8 muscle regarding the thymuses and you can spleens from Blk-lacking mice were like during the 129/Sv manage rats (studies not found). I as well as didn’t choose any difference in T-telephone receptor ??, CD3?, heat-steady antigen, and you may CD69 term from inside the splenic T-cell and you can thymocyte subpopulations out-of control and you may Blk-lacking rats (studies not shown). Protein tyrosine phosphorylation. The fresh role from Blk within the BCR-created signaling are managed of the research out of skin IgM-mediated tyrosine phosphorylation out of intracellular necessary protein during the filtered splenic B cells. The latest models out-of korealainen morsiamet phosphoproteins entirely-mobile lysates away from unstimulated and you will anti-IgM-managed 129/Sv […]